New research indicates that people who come off popular GLP-1 drugs like semaglutide or tirzepatide can put back on shed pounds much more quickly than those who stop conventional diet and exercise programs.
Research printed in a leading medical journal shows that while overweight individuals can lose substantial amounts of their body weight while on the medication, the mass comes back at an average rate of nearly a kilo each month upon discontinuation.
"People using such medications should be aware of the danger of rapid rebound weight gain when the treatment concludes," warns researcher Dr. Susan Jebb.
Such speed of recovery implies a return to pre-treatment mass in about a year and a half.
Comparing Treatments
The research, which examined dozens of trials involving thousands of participants, compared the outcomes of GLP-1 agonists with conventional dieting.
Scientists point out that individuals who lose weight through diet and exercise typically experience a more gradual weight regain—perhaps 0.1 kg a month—once they finish.
Explaining the Fast Regain
Experts propose the way of the jabs explains the accelerated weight return.
GLP-1 drugs imitate a body's own chemical called glucagon-like peptide-1, which moderates appetite.
"Long-term administration of GLP-1 levels far above than the body's typical production may cause the body to produce less of its own natural hormone, and may also reduce sensitivity to its actions," noted Dr. Adam Collins, a nutrition researcher.
"Withdrawal of this hormone supplement leads to hunger is unsuppressed, making overeating a significant risk."
A Chronic Issue?
The NHS suggest the jabs for people with obesity-related health risks, accompanied by prescribed diet and exercise modifications.
Professionals contend that, due to the significant potential of relapse, the therapy might need to be ongoing.
This view is reinforced by drug manufacturers, who say that the results "highlight the long-term nature of excess weight," akin to managing conditions like high blood pressure.
User Accounts
People who have stopped the medication describe a sudden return of hunger.
"I experienced something flipping and I was suddenly starving," said one woman.
This difficulty is exacerbated if users have not adopted lasting dietary or behavioural changes during therapy.
Widespread Adoption
Figures suggest that millions of adults in the UK have tried these injections in the past year, with demand remaining high.
- Adoption is greater among women compared to men.
- The middle-aged age group shows the greatest usage rates.
- Many obtain the medications through private prescriptions rather than public health services.
Finally, experts stress that while these medications are effective tools for weight loss, they are not a standalone cure and maintained weight loss likely depends on integrated lifestyle changes.
